Isocitrate dehydrogenase 1: what it means to the neurosurgeon
نویسندگان
چکیده
منابع مشابه
Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.
Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered to be frequent and highly conserved in secondary glioblastoma multiforme and lower-grade gliomas. Although IDH1 mutations confer a unique genotype that has been associated with a favorable prognosis, the role of the mutated IDH1 enzyme and its metabolites in tumor initiation and maintenance remains unresolved. However, given that ...
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ژورنال
عنوان ژورنال: Journal of Neurosurgery
سال: 2013
ISSN: 0022-3085,1933-0693
DOI: 10.3171/2013.3.jns122282